Go big or stay home!! If you have a business and it's growing, get the biggest DC unit you can afford (then upgrade from there) and start with 6" duct work. Once you have a big system you can always add on instead of replacing. Start big and you will never regret it. I have a 3HP Grizzly unit that lives OUTSIDE my shop and just blows the dust into a pile. I used 4" black sewer pipe for duct and built my own blast gates out of 1/4 PVC sheet material. Each gate has a micro switch wired in series to hold the start relay for the unit motor. When you open a gate, the unit starts. The effectiveness of my system has more to do with the "hook-up" to the machine than the size of the unit. If I were to start over I'd use the same unit but bigger (6") duct pipe.
Good luck!!