You can make that HF DC work, however...
#1. You really must upgrade the filter from the 5 micron bag to a 1 micron or lower filtering cartridge to keep the ultra fine dust IN the collector...
#2. If you can afford to, especially with the short runs you are talking about, I would try to arrange it so everything is on one 6" main and branches. Using proper blast gates. I know 6" is a pain to get, and expensive. There is a reason I am using 4". I am not going to assert like others here that 4" can't work, there is just too much evidence it can, and does when set up right, BUT, it is really pushing it to make it work the way it should... While the fittings on HF DC are for 5", you can modify that DC to accept a 6" duct.
#4. Unless you are running the Veritas separator lid, I don't know of a commercially available separator lid that is all that effective. Consider building yourself a Thien separator lid. They really don't take that long to build, and do a top notch job and separating your chips, AND most of your fines...
#5. Rod really nailed down what you need to do on the machines. It takes some tinkering. Including in my case, making prototype hoods from cardboard and duct tape to find something that works before I commit to something more permanent...
#6. Even with the best dust collection system, you WILL miss some of the fines. You need an ambient air fliter of some sort, and may want to use a respirator...
IF you can afford one, a Dylos or similar particle meter would go a LONG way to helping you figure out how effective your dust collection / control efforts are...
Trying to follow the example of the master...