Umm, honestly no idea. It could work but I don't want to speculate. You could try it and if it comes apart later on, replacing it an 8/4 or thicker chop probably wouldn't be to hard.
Do it.... You know you want too! Yes, the apron sits on a lap joint in the leg, and serves as the long stretcher at the top. At least in the Nicholson design it does. Why not do something like in the pic I linked to previously? Make the leg that the vise will be attached to really wide. I would think you could mortise it straight into the top and by keeping it wide just cut the long edge grain at the angle you want the vise to be at. I cant say with any certainty that this would work, but I bet if you toyed with the design for a while you could come up with a solid plan.