Aaron
I assume you will want 220V available in the garage. Usually the rating given for a panel/subpanel is it's max 220V input. A given panel can be used for a lower capacity, usually isn't, unless reserving space for future upgrades. If you want 100A of 220V capacity in your garage subpanel, then you need a 100A 220V breaker in the main panel, which will have a 100A breaker on each hot leg, which are mechanically tied together into a single unit. An electrician would probably run a 1/0 (One Ought) aluminum for 100A service.
If you want 100A of 110V service, then you could use a 50A 220V breaker in the main, with possibly 8ga, but more likely 6ga leads.
Strongly recommend you have a licensed electrician do this work, if only for the fact that 1/0 wiring is a bear to work with without the proper tools!!!
Good luck.