I've cut it with a bandsaw before and had reasonable luck. I made a fairly short cut - two feet or so - stopped the saw and cleaned the melted and rehardened plastic off things and repeated the process. I tried it with a tablesaw and threw little bits of plexiglass all over. I sandwiched it between two scrap pieces of plywood and it helped make a smoother cut but still had breaks along the edges that ran in at shallow angles about an inch.

I've cut similar things with a circular saw with the blade reversed, but never thought about doing the same thing with a tablesaw blade. D'oh! You might call a glass company and ask what they use.