Not 100% sure what's around in the US now, and what the makers are claiming re. full HEPA filters - until recently at least it seemed like properly certified items were not readily available.
Pressure drop won't be a problem provided you install enough filter area. Sizing/square footage will be determined by the rate of recirculation of air you decide you want - but that's a bit of a double edged sword by all accounts in that if you get into high enough airflows you may also (at least temporarily) raise a lot of dust in the workshop. Effective diffusion may be important. i.e. exhausting through a bag or something over a large area so that it wouldn't create draughts.
The other issue though is that if too much fine dust is making it into the air (whatever about the effect on your lungs) because your at source dust collection system is not working very well the filters may blind up too quickly. i.e. effective at source collection is going to matter anyway.
I don't think you're going to get anybody providing genuinely definitive information for a system along the lines you are thinking of - in that even if the work has been done, and even if an effective system can be achieved via this route it doesn't seem widely published or used. There may just be a reason for this....
The other way of looking at it is that experience says that a high CFM Pentz style dust collection system seems to work pretty well as an air cleaner anyway - whether it does so by drawing in fresh air to replace that which has been exhausted, or recirculates it through a set of high quality filters. (they are easily set up so that both options are available by opening a blast gate) In a smaller workshop like i have anyway....
If you're already on the DIY road to build some sort of super air cleaner, and already committed to reworking the dust collection system by buying a cyclone to drop out chips before exhuasting the rest, and are going to need/already have properly sized ducting to get effective at source collection then maybe there's no reason why you shouldn't alternatively and for similar input build a Pentz style system - it'd only require buying a 16in Clear Vue impeller and motor to suit... (the rest can be built DIY as i did)
Which if true would bring it down to the question of which solution is likely to deliver the best results in terms of air quality and serviceability...
ian