Geoff, one of the biggies for transition to a slider is to get comfortable with clamping a board on the wagon for the rip cut as well as rethinking things that you might have used miter slots for in the past. Further, the safety factor goes up big-time as your hands and body are nowhere near the blade and the material is securly fastened to the machine. It just takes getting used to...processes are different, not difficult...and given that we humans are creatures of habit, it's largely a matter of "re-training" yourself.
As Paul has shown (as well as Sam Blasco and his wonderful jigs and adapters) there really isn't anything you can't accomplish with these saws.
Todd hinted that I'm considering one of these machines "as we speak"...and I work almost exclusively in solid woods. (Some of the cabinetry for our addition will be an exception to that for obvious reasons) I'm convinced that the benefits are great and that was reinforced by reading the piece by Mark Duginski that Todd posted about the other day. (It's in an insert that came with Woodshop News this week, too)
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The most expensive tool is the one you buy "cheaply" and often...